ごあいさつ

スタッフ紹介

所長

伊藤 和幸

研究テーマ:細胞内シグナル伝達系による生体の機能調節と臨床への応用

履歴
1983年 3月
山口大学医学部卒業 (医籍登録278798、83-6-28)
1987年 3月
大阪大学医学部大学院修了 医学博士 (阪大医7640、87-3-26)
1987年 4月
大阪大学医学部第4内科
1989年 2月
大阪府立成人病センター研究所
1992年 7月
米国国立予防衛生研究所 (NIH) Visiting Associate
1995年10月
大阪府立成人病センター研究所
2001年 4月
大阪府立成人病センター研究所生物学部門長
2010年 4月
大阪府立大学大学院生命環境科学研究科客員教授~2013.3
2011年 4月
大阪府立成人病センター研究所病理学部門長(兼任)~2014.9
2011年 4月
信州大学大学院医学系 研究科 客員教授~2014.3.
2016年 4月
野崎徳州会病院 研究所長、内科部長
受賞等
1992年 4月
1992年度日本心臓財団海外留学助成
1999年 5月
第3回がん転移学会奨励賞
1999年11月
第38回ベルツ賞
委員等
文部科学省 科学研究費補助金専門委員
学会
日本がん転移学会(前会長、事務局幹事)
国際転移学会(Board of Directors(理事))
日本癌学会(評議員)
日本生化学会
日本心血管内分泌代謝学会
米国細胞生物学会
Editorial Board: Clinical and Experimental Metastasis, Journal of Orthopedic Science
主要発表論文
Itoh, K. and Adelstein, R. S.: Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B: J. Biol. Chem. 270: 14533-14540 (1995)
Rochlin, M. W., Itoh, K., Adelstein, R. S. and Bridgeman P. C.: Localization of myosin II A and B isoforms in cultured neurons: J. Cell Sci. 108: 3661-3670 (1995)
Yoshioka, K, Matsumura, F., Akedo, H. and Itoh, K.: Small GTP-binding Protein Rho Simulates the Actomyosin System, Leading to Invasion of Tumor Cells: J. Biol. Chem. 273: 5146-5154 (1998)
Asai, T., Ueda, T., Itoh, K., Yoshioka, K., Aoki, Y., Mori S. and Yoshikawa H.: Establishment and characterization of a murine osteosarcoma (LM8) with high metastatic potential to the lung: Int. J. Cancer 76: 418-422 (1998)
Itoh, K., Yoshioka, K., Akedo, H., Uehata, M., Ishizaki, T. and Narumiya, S.: An essential part for Rho-associated kinase in the transcellular invasion of tumor cells: Nature Medicine 5: 221-225 (1999)
Yoshioka, K., Nakamori, S. and Itoh, K.: Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells: Cancer Research 59: 2004-2010 (1999)
Itoh, K. and Yoshioka, K.: Molecules that allow tumor cells to invade new tissues: ASCB Press Book : 4-5 (1999)
Manzanares, MV., Cabrero JR., Rey, M., Martínez, MP., Ursa, A., Itoh, K.and Madrid, FS.:A role for the Rho-p160Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1-induced lymphocyte actomyosin and microtubular organization and chemotaxis: J. Immunology 168: 400-410 (2002)
Naka, M., Araki, N., Nakanishi, H., Itoh, K., Mano, M., Ishiguro, S., Brujin, DR., Myoui, A., Ueda, T. and Yoshikawa, K.: Expression of SSX genes in human osteosarcomas: Int. J. Cancer 98: 640-642 (2002)
Higuchi, C., Myoui, A., Hashimoto, N., Kuriyama, K., Yoshioka, K., Yoshikawa, H. and Itoh, K.: Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of extracellular matrix: J. Bone Miner. Res.17: 1785-1794 (2002)
Kuriyama, K., Higuchi, C., Tanaka, K., Yoshikawa, H. and Itoh, K.: A novel anti-rheumatic drug, T-614, stimulates osteoblastic differentiation in vitro and bone morphogenetic protein-2 induced bone formation in vivoBiochem. Biophys. Res. Commun.299: 903-909 (2002)
Manzanares, MV., Rey, M., Martínez, MP., Mo, MY, Sancho, D., Cabrero JR., Barreiro, O., Fuente, H., Itoh, K. and Madrid, FS.: The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes: J. Immunology 171: 1023-1034 (2003)
Yoshioka, K., Foletta, V., Bernard, O. and Itoh, K.: A Role for LIM-Kinase in Cancer Invasion: Proc. Natl. Acad. Sci. USA. 100: 7247-7252 (2003)
Nishimura, Y., Itoh, K., Yoshioka, K., Tokuda, K. and Himeno, M.: Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes: Pathology Oncology Res. 9:83-95 (2003)
Nakanishi, H., Yoshioka, K., Joyama, S., Araki, N., Myoui, A., Ishiguro, S., Ueda, T., Yoshikawa, H., and Itoh, K.: IL-6/soluble IL-6R Signaling Attenuates Proliferation and Invasion, and Induces Morphological Changes of a Newly Established Pleomorphic Malignant Fibrous Histiocytoma Cell Line: Am. J. Pathol. 165: 471-480 (2004)
Itoh, K., Joyama, S., Naka, N., and Yoshioka, K.: SSX: new molecular target regulating cancer cell invasion: Clin. Exp. Metastasis. 21:617 (2004)
Naka, N., Joyama, S., Tsukamoto, Y., Yoshioka, K., Hashimoto, H., Ujiiye T., Hayashi, T., Kawase, M., Mano, M., Ishiguro, S., Myoui, A., Ueda, T., Yoshikawa, H., Araki, N., and Itoh, K.: Quantification of SSX mRNA expression in human bone and soft tissue tumors using Nucleic Acid Sequence-Based Amplification (NASBA): J. Mol. Diagn. 7:187-197 (2005)
Nakagawa, H., Yoshioka, K., Miyahara, E., Fukushima, Y., Tamura, M., and Itoh, K.: Intrathecal administration of Y-27632, a specific ROCK inhibitor, for rat neoplastic meningitis: Mol. Cancer Res., 3: 425-433, cited on the cover (2005)
Zhang, X., Lin, M., van Golen, KL, Yoshioka. K., Itoh K., and Yee, D.: Multiple signaling pathways are activated during Insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration: Breast Cancer Res Treat., 93: 159-168 (2005)
Jomgeow, T., Oji, Y., Tsuji, N., Ikeda, Y., Ito, K., Tsuda, A., Nakazawa, T., Tatsumi, N, Sakaguchi, N., Takashima, S., Shirakata, T., Nishida, S., Hosen, N., Kawakami, M., Tsuboi, A., Oka, Y., Itoh, K., and Sugiyama, H.: Wilms’ tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion: Cancer Sci. 97: 259-270 (2006)
Joyama, S., Naka, N., Tsukamoto, Y., Yoshikawa, H., and Itoh, K.: Dendritic Cell Immunotherapy for Lung Metastasis from Murine Osteosarcoma: Clin. Orthop. Relat. Res. 453: 318-327 (2006)
Sotobori, T., Ueda, T., Myoui, A., Yoshioka, K., Nakasaki, M., Yoshikawa, H., and Itoh, K.: Bone morphogenetic protein-2 promotes the haptotactic migration of murine osteoblastic and osteosarcoma cells by enhancing incorporation of integrin 1 into lipid rafts: Exp. Cell Res. 312:3927-3938 (2006)
Fukushima, Y., Tamura, M., Nakagawa, H., and Itoh, K.: Induction of glioma cell migration by Vitronectin in human serum and cerebrospinal fluid:J. Neurosurg. 107: 578-585 (2007)
Yamate, J., Ogata, K., Yuasa, T., Kuwamura, M., Takenaka, S., Kumagai, D., Itoh K., and LaMarre., J.; Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells: Eur J. Cancer 43:2747-2756 (2007)
Nishimura, Y., Yoshioka, K., Bereczky, B., and Itoh, K.: Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line: Mol Cancer 7:42 (2008)
Baba, M., Inoue, M., Itoh, K. and Nishizawa, Y.: Blocking CD147 induces cell death through impairment of glycolytic energy metabolism: Biochem. Biophys. Res. Commun. 374: 111-116 (2008)
Nakasaki, M., Yoshioka, K., Miyamoto, Y., Sasaki T., Yoshikawa, H., and Itoh, K.: IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts: Bone 43:869-879 (2008)
Steeg, PS., Anderson, RL., Bar-Eli, M., Chambers, AF., Eccles, SA., Hunter, K., Itoh, K., Kang Y., Matrisian LM., Sleeman JP., Theodorescu D., Thompson EW., and Welch, DR.: Preclinical drug development must consider the impact on metastasis: Clin. Cancer Research 15:4529-4530 (2009)
Yoshikawa, H., Yoshioka, K., Nakase, T., and Itoh, K.: Stimulation of Ectopic Bone Formation in Response to BMP-2 by Rho-associated Kinase Inhibitor-A pilot study: Clin. Orthop. Relat. Res. 467:3087-3095 (2009)
Takenaka, S., Naka, N., Araki, N., Hashimoto, N., Ueda, T., Yoshioka, K., Yoshikawa, H. and Itoh, K.: Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo: Int J Oncology 36:823-831 (2010)
Naka, N., Takenaka, S., Araki, N., Miwa, T., Hashimoto, N., Yoshioka, K., Joyama, S., Hamada, K., Tsukamoto, Y., Tomita, Y., Ueda, T., Yoshikawa, H., and Itoh K.: Synovial sarcoma is a stem cell malignancy: Stem Cells 28:1119-1131 (2010)
Yui, Y., Itoh, K., Yoshioka, K., Naka, N., Watanabe, M., Hiraumi, Y., Matsubara, H., Watanabe, K., Sano, K., Nakahata, T. and Adachi S.: Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8: Clin Exp Metastasis 27: 619-630 (2010)
Sonoshita, M., Aoki, M., Fuwa, H., Aoki K., Hosogi, H., Sakai, Y., Hashida, H., Takabayashi, A., Sasaki, M., Robine, S., Itoh, K., Yoshioka, K., Kakizaki, F., Kitamura, T., Oshima, M. and Taketo. M. M.: Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling: Cancer Cell 19: 125-137 (2011)
Ichida, M., Yui Y., Yoshioka K., Tanaka T., Wakamatsu T., Yoshikawa H. and Itoh K.: Changes in cell migration of mesenchymal cells during osteogenic differentiation: FEBS Letters: 585: 4018-4024 (2011)
Tanaka, T., Yui, Y., Naka, N., Wakamatsu, T., Yoshioka, K., Araki, N., Yoshikawa, H. and Itoh, K.: Dynamic analysis of lung metastasis by mouse osteosarcoma LM8-VEGF is a candidate for anti-metastasis therapy: Clin Exp Metastasis30: 369-379 (2013)
Nishimura, Y., Takiguchi, S., Ito, S. and Itoh, K.: Evidence that depletion of the sorting nexin 1 by siRNA promotes HGF-induced MET endocytosis and MET phosphorylation in a gefitinib-resistant human lung cancer cell line:Int J Oncology 44: 412-426 (2014)
Yasui, H., Naka, N., Imura, Y., Outani, H., Kaneko, K., Hamada, K., Sasagawa, S., Araki, N., Ueda, T., Itoh, K., Myoui, A. and Yoshikawa, H.: Tailored therapeutic strategies for synovial sarcoma: Receptor tyrosine kinase pathway analyses predict sensitivity to the mTOR inhibitor RAD001: Cancer lett 347:114-122 (2014)
Outani, H., Tanaka, T., Wakamatsu, T., Imura, Y., Hamada, K., Araki, N., Itoh, K., Yoshikawa, H. and Naka, N.: Establishment of Hewga-clear cell sarcoma, a new clear cell sarcoma cell line, and investigation of the antitumor effects of pazopanib on Hewga-CCS: an in vitro and in vivo study: BMC Cancer: 14:455 (2014)
Wakamatsu, T., Naka, N., Sasagawa, S., Tanaka, T., Takenaka, S., Araki, N., Ueda, T., Yoshioka, K., Nishizawa, Y., Yoshikawa, H. and Itoh, K.: Deflection of VEGF action by SS18-SSX and composite VEGF- and CXCR4-targeted therapy in synovial sarcoma: Cancer Science: 105: 1124-1134 (2014)
Imura, Y., Yasui, H., Outani, H., Wakamatsu, T., Hamada, K., Nakai, T., Yamada, S., Myoui, A,, Araki, N., Ueda, T., Itoh, K., Yoshikawa, H., and Naka, N.: Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma: Mol Cancer 13(1):185 (2014)
Itoh, K.: Basic Research for Osteosarcoma Lung Metastasis (LM8): chapter 18 in “Osteosarcoma” edited by Drs. Ueda, T. and Kawai, A. by Springer (2014)
Nishimura, Y., Takiguchi, S., Ito, S. and Itoh, K.: EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line:Int J Oncology 46: 1721-1729 (2015)
Yasui, H., Imura, Y., Outani, H., Hamada, K., Nakai, T., Yamada, S., Takenaka, S., Sasagawa, S., Araki, N., Itoh, K., Myoui, A., Yoshikawa, H. and Naka, N.: Trabectedin is a Promising Anti-tumor Agent for Synovial Sarcoma: Journal of Chemotherapy: Jan 29: 1-8 (2016)
Fukuda, H., Chisaki, Y., Takada, T., Toda, Y., Murata, H., Itoh, K., Yano, Y., Takata, K., and Ashihara, E.: Daphnetin Inhibits Invasion and Migration of LM8 Murine Osteosarcoma Cells by Decreasing RhoA and Cdc42 Expression: Biochem. Biophys. Res. Commun. : 471:63-67 (2016)
Nishimura, Y., Hyuga, S., Takiguchi, S., Hyuga, M., Itoh, K. and Hanawa, T.: Ephedrae stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathway in a gefitinib-resistant human lung cancer cell line:Int J Oncology: 48:1895-1906 (2016)
Imura, Y., Nakai, T., Yamada, S., Outani. H., Takenaka. S., Hamada, K., Araki, N., Itoh, K., Yoshikawa, H., and Naka, N.: Functional and therapeutic relevance of hepatocyte growth factor/c-MET signaling in synovial sarcoma: Cancer Science: 107(12): 1867-1876 (2016)
Yamada, S., Imura, Y., Nakai, T., Nakai, S., Yasuda, N., Kaneko. K., Outani. H., Takenaka. S., Hamada, K., Myoui, A., Araki, N., Ueda, T., Itoh, K., Yoshikawa, H., and Naka, N : Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma: BMC Cancer in press (2017)
Nakai, T., Imura, Y., Tamiya., Yamada, S., Nakai, S., Yasuda, N., Kaneko, K., Outani, H., Takenaka, S., Hamada, K., Myoui, A., Araki, N., Ueda, T., Itoh, K., Yoshikawa, H., and Naka, N.: Trabectedin is a promising antitumor agent potentially inducing melanocytic differentiation for clear cell sarcoma: Cancer Medicine in press (2017)

詳細なCV

副所長
病理学研究部長
大阪大学薬学部非常勤講師

西澤 恭子

研究テーマ:
1.ステロイドホルモン依存性腫瘍増殖のメカニズム
2.ビタミンB12・漢方薬による腫瘍増殖制御

学位・資格
1975年 3月
大阪大学医学部医学科 卒業
1985年 2月
大阪大学医学博士
医師免許
死体解剖資格-病理解剖-
日本病理学会認定病理医、病理専門医研修指導医
日本人類遺伝学会認定臨床遺伝専門医
日本内科学会認定内科医
日本内分泌学会認定内分泌代謝科(内科)専門医
第1種放射線取扱主任者
所属学会
日本病理学会
日本人類類遺伝学会
日本内科学会
日本内分泌学会
日本アンドロロジー学会
日本癌学会
主要論文
Endo, H., Okami, J., Okuyama, H., Nishizawa, Y., Imamura, F. and Inoue, M. The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations. Oncogene (2016) 1-11
Akazawa, T., Ohashi, T., Nakajima, H., Nishizawa, Y., Kodama, K., Sugiura, K., Inaba, T. and Inoue, N. (2014)Development of a dendritic cell-targeting lipopeptide as an immunoadjuvant that inhibits tumor growth without inducing local inflammation. Internat. J. Cancer. DOI: 10 1002/ijc28939
Endo, H., Okami, J., Okuyama, H., Kumagai, T., Uchida, J., Kondo, J., Takehara, T., Nishizawa, Y., Imamura, F., Higashiyama, M. and Inoue, M. (2013) Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation. J. Thorac. Oncol. 8, 131-139
Murashima, T., Katayama, H., Nishizawa, Y., Kimura, S. and Nishizawa, Y. (2011) Possible mechanism of growth inhibition by Scutellaria baicalensis in an estrogen-responsive mouse tumor cell line. Oncol. Rep., 25, 1431-1438
Katayama, H., Murashima, T., Saeki, Y. and Nishizawa, Y. (2010) The pure anti-androgen bicalutamide inhibits cyclin A expression both in androgen-dependent and -independent cell lines. Int. J. Oncol., 36, 553-562
Goto, G.H., Katayama, H., Tanigaki, Y., Fushiki, S., Nishizawa, Y. and Nishizawa, Y. (2008) Methylcobalamin inhibits fibroblast growth factor-8 stimulated proliferation and induces apoptosis in Shionogi carcinoma cells. Int. J. Vitam. Nutr. Res., 78, 21-26
Nishizawa, Y., Goto, G.H., Tanigaki, Y., Fushiki, S. and Nishizawa, Y. (2001) Induction of apoptosis in an androgen-dependent mouse mammary carcinoma cell line by methylcobalamin. Anticancer Res., 21, 1107-1110.
Nishizawa, Y., Yamamoto, T., Tanigaki, Y., Kasugai, T., Mano, M., Ishiguro, S., Fushiki, S., Poirier, L.A. and Nishizawa, Y. (1999) Methylcobalamin decreases mRNA levels of androgen-induced growth factor in androgen-dependent Shionogi carcinoma 115 cells. Nutrition and Cancer, 35, 195-201.
Nishii, K., Nishizawa, Y., Nishizawa, Y., Matsumoto, K. and Sato, B. (1991) Inhibition of murine transformed Leydig cell proliferation by leukotrienes in serum-free culture. Cancer Res., 51, 5573-5578.
Nishizawa, Y., Nishii, K., Nishizawa, Y., Koga, M., Kishimoto, S., Matsumoto, K. and Sato, B. (1990) Effects of estrogen on cell proliferation and leukotriene formation in transformed mouse Leydig cells cultured under serum-free conditions. Cancer Res., 50, 3866-3871.

西 正吾

研究テーマ:

学位・資格
所属学会
主要論文

悪性腫瘍新規治療法開発研究部長
小児科医長

由井 理洋

研究テーマ:骨軟部腫瘍の転移メカニズム解明と抗転移療法の開発

学位・資格
2009年
京都大学大学院医学研究科発達小児科学 博士課程修了
2001年
京都大学医学部卒業
日本小児科学会専門医
所属学会
日本がん転移学会 (評議員)
日本癌学会
日本小児科学会
主要論文
Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nature Medicine. 2014, 20(4): 360-367.
Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Research. 2014, 74(17): 4597-4611.
Tanaka T, Yui Y, Naka N, Wakamatsu T, Yoshioka K, Araki N, Yoshikawa H, Itoh K. Dynamic analysis of lung metastasis by mouse osteosarcoma LM8: VEGF is a candidate for anti-metastasis therapy. Clin. Exp. Metastasis. 2013, 30(4): 369-379.
Ichida M, Yui Y, Yoshioka K, Tanaka T, Wakamatsu T, Yoshikawa H, Itoh K. Changes in cell migration of mesenchymal cells during osteogenic differentiation. FEBS letters. 2011; 24: 4018-4024
Yui Y, Itoh K, Yoshioka K, Naka N, Watanabe M, Hiraumi Y, Matsubara H, Watanabe K, Sano K, Nakahata T, Adachi S. Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8. Clin. Exp. Metastasis. 2010; 27: 619-630

分子生物学研究部長
動物実験施設 施設長(兼)

笹川 覚

研究テーマ:細胞運命決定の分子メカニズムと骨軟部腫瘍転移の分子基盤の解明

学位・資格
2002年
名古屋大学大学院人間情報学研究科 博士(学術)
所属学会
日本癌学会
日本分子生物学会
主要論文
Takeda S, Sasagawa S, Oyama T, Searleman AC, Westergard TD, Cheng EH, Hsieh JJ.Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.Journal of Clinical Investigation, 125(3), 1203-1214, 2015.
Oyama T(※), Sasagawa S(※), Takeda S, Hess RA, Lieberman PM, Cheng EH, Hsieh JJ.Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.Developmental Cell, 27(2), 188-200, 2013. ※Co-first author
Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, Tsumaki N.SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice.Development, 139(6), 1153-1163, 2012.
Sasagawa S, Ozaki Y, Fujita K, Kuroda S.Prediction and validation of the distinct dynamics of transient and sustained ERK activation.Nature Cell Biology, 7(4), 365-373, 2005.
Sasagawa S, Takabatake T, Takabatake Y, Muramatsu T, Takeshima K Axes establishment during eye morphogenesis in Xenopus by coordinate and antagonistic actions of BMP4, Shh, and RA.Genesis, 33(2), 86-96, 2002.

内科医師 兼 主任研究員

酒井 喜久

研究テーマ:Applied research of the Heart Specific Binding Peptide (HSBP) for heart diseases.

学位・資格
1988年
M.D., Gifu University, School of Medicine, Gifu, Japan.
1993年
Ph.D., Department of Pathology, Nagoya University, School of Medicine, Nagoya, Japan.
職歴
1997年
Department of Otolaryngology, University of South Florida, Tampa, FL.
1999年
Powell Gene Therapy Center, University of Florida, College of Medicine, Gainesville, FL.
2006年
Department of Urology, University of Florida, College of Medicine, Gainesville, FL.
2008年
Department of Otolaryngology-Head and Neck Surgery, University of South Florida, Tampa, FL.
2015年
VA Medical Center-San Francisco, San Francisco, CA.
2016年
Icahn School of Medicine at Mount Sinai, New York, NY.
2017年
野崎徳洲会病院附属研究所
主要論文
Zolotukhin S, Potter M, Zolotukhin I, Sakai Y, Loiler S, Fraites TJ Jr, Chiodo VA, Phillipsberg T, Muzyczka N, Hauswirth WW, Flotte TR, Byrne BJ, Snyder RO. (2002) Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods 28(2):158-167.
Sakai Y, Sokolowski BH, Harvey MC, Duzhyy DE. (2004) Identification and localization of an arachidonic acid-sensitive potassium channel in the cochlea. J. Neurosci. 24(28):6265-6276.
Duzhyy DE, Sakai Y, Sokolowski BH. (2004) Cloning and developmental expression of Shaker potassium channels in the cochlea of the chicken. Brain Res. Mol. Brain Res. 121(1-2):70-85.
Dunn WA Jr, Cregg JM, Kiel JA, van der Klei IJ, Oku M, Sakai Y, Sibirny AA, Stasyk OV, Veenhuis M. (2005) Pexophagy: the selective autophagy of peroxisomes. Autophagy. 1(2):75-83.
Kusmartsev S, Eruslanov E, Kübler H, Tseng T, Sakai Y, Su Z, Kaliberov S, Heiser A, Rosser CJ, Dahm P, Siemann D, Vieweg J. (2008) Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma. J. Immunol. 181(1):346-353.
Cao W, Shiverick KT, Namiki K, Sakai Y, Porvasnik S, Urbanek C, Rosser CJ. (2008) Docetaxel and bortezomib downregulate Bcl-2 and sensitize PC-3-Bcl-2 expressing prostate cancer cells to irradiation. World J. Urol. 26(5):509-516.
Pacak CA, Sakai Y, Thattaliyath BD, Mah CS, Byrne BJ. (2008) Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice. Genet. Vaccines Ther. 6:13.
Cao W, Yacoub S, Shiverick KT, Namiki K, Sakai Y, Porvasnik S, Urbanek C, Rosser CJ. (2008) Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate 68(11):1223-1231.
Sakai Y, Goodison S, Kusmartsev S, Fletcher B, Eruslanov E, Cao W, Porvasnik S, Namiki K, Anai S, Rosser CJ. (2009) Bcl-2 mediated modulation of vascularization in prostate cancer xenografts. Prostate 69(5):459-470.
Sakai Y, Goodison S, Cao W, Urquidi V, Namiki K, Porvasnik S, Urbanek C, Rosser CJ. (2009) VEGF induces expression of Bcl-2 and multiple signaling factors in microvascular endothelial cells in a prostate cancer model. World J. Urol. 27(5):659-666.
Anai S, Sakamoto N, Sakai Y, Tanaka M, Porvasnik S, Urbanek C, Cao W, Goodison S, Rosser CJ. (2011) Dual targeting of Bcl-2 and VEGF: A potential strategy to improve therapy for prostate cancer. Urol. Oncol. 29(4):421-429.
Harvey MC, Karolat J, Sakai Y, Sokolowski BHA. (2009) PPTX a pentraxin domain-containing protein interacts with the T1 domain of Kv4. J. Neurosci. Res. 87(8):1841-1847.
Kathiresan T, Harvey M, Orchard S, Sakai Y, Sokolowski B. (2009) A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Mol. Cell Proteomics 8(8):1972-1987.
Mitchell M, Nam HJ, Carter A, McCall A, Rence C, Bennett A, Gurda B, McKenna R, Porter M, Sakai Y, Byrne BJ, Muzyczka N, Aslanidi G, Zolotukhin S, Agbandje-McKenna M. (2009) Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9. Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun. 65(7):715-718.
Sippel KH, Boehlein SK, Sakai Y, Quirit JG, Agbandje-McKenna M, Rosser CJ, McKenna R. (2009) Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289. Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun. 65(9):910-912.
Al-Mousily F, Mcauliffe P, Sakai Y, Thattaliyath B, Onal T, Embury J, Spencer C, Byrne BJ. (in preparation) Overexpression of elafin in the treatment of pulmonary hypertension using AAV1 vector in rat model.
Sakai Y, Harvey MC, Sokolowski B. (2011) Identification and quantification of full length BK channel variants in the developing mouse cochlea. J. Neurosci. Res. 89(11):1747-1760.
Sokolowski BHA, Orchard S, Harvey M, Sridhar S, Sakai Y. (2011) Conserved BK Channel-Protein Interactions Reveal Signals Relevant to Cell Death and Survival. PLoS ONE 6(12):e28532.
19) Sokolowski S, Harvey M, Sakai Y, Jordan A, Sokolowski B. (2012) The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b. Biochem. Biophys. Res. Commun. 426(2):221-225.
Ding B, Frisina RD, Zhu X, Sakai Y, Sokolowski B, Walton JP. (2014) Direct control of Na(+)-K(+)-2Cl(-)-cotransport protein (NKCC1) expression with aldosterone. Am. J. Physiol. Cell Physiol. 306(1):C66-75.
Peng Z, Sakai Y, Kurgan L, Sokolowski B, Uversky V. (2014) Intrinsic disorder in the BK channel and its interactome. PLoS One 9(4):e94331.
Sakai Y, Sokolowski B. (2015) The large conductance calcium-activated potassium channel affects extrinsic and intrinsic mechanisms of apoptosis. J. Neurosci. Res. 93(5):745-754.
Sakai Y, Sokolowski B. (submitted) The Voltage-gated Potassium Channel, Kv1.2, is Associated with Tumorigenesis in Squamous Cell Carcinoma.
Sakai Y, Sokolowski B. (submitted) The large conductance calcium-activated potassium channel regulates the cell cycle through the Akt pathway.
特許
1) 1. Name: Yoshihisa Sakai, UF#- 15426 entitled "PXYZ5", UFID Number: 35444860. U.S. PatentApplication Serial Number: 10/456,423, June 5, 2003.Reference: Zolotukhin S, Potter M, Zolotukhin I, Sakai Y, Loiler S, Fraites TJ Jr, Chiodo VA, Phillipsberg T, Muzyczka N, Hauswirth WW, Flotte TR, Byrne BJ, Snyder RO (2002). Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods 28(2):158-167.
2) 2. Name: Yoshihisa Sakai, U.S. Provisional Application No.: 62/266,475. Title: HEART SPECIFIC BINDING PEPTIDES AND USES THEREOF.University of Florida Research Foundation, Inc. Ref. No.: 15928.Wolf, Greenfield & Sacks, P.C. Ref. No.: U1197.70075US00.

膠原病リウマチ内科医師 兼 主任研究員

高橋 令子

研究テーマ:
可塑性を含む制御性T細胞の抑制機能異常と全身性エリテマトーデスの病態の関係の解明
全身性エリテマトーデスなど膠原病の患者検体解析と疾患特異的な治療法の開発

学位・資格
1997年3月31日
山形大学医学部医学科卒業
1997年4月 1日
山形大学大学院医学系研究科医学専攻外科学第二入学
2001年3月31日
同上 修了
職歴
2001年4月1日
筑波大学附属病院臨床医学系シニアレジデント(膠原病・リウマチ・アレルギー内科)
2004年4月1日
米国オクラホマ医学研究財団post-doc (Arthritis and immunology program)
2005年10月1日
東北大学病院助教 (血液免疫科)
2009年1月1日
慶應義塾大学医学部特別研究助教 (微生物学免疫学教室)
2012年3月1日
防衛医科大学校内科学助教 (血液膠原病アレルギー内科)
2015年7月1日
九州大学別府病院准教授(共同研究部門 リウマチ膠原病内科学)
2017年2月1日
野崎徳洲会附属研究所 医師兼研究員
所属学会
日本内科学会  (認定医;認定番号:33302)
日本リウマチ学会 (専門医;認定番号:4657、評議員:2013年~現在)
日本免疫学会
日本臨床免疫学会 (評議員:2013年~現在)
日本ウイルス学会
受賞等
2002年
難病医学研究財団海外派遣研究助成金 授与
2004年
日本リウマチ財団海外派遣研究奨学金 授与
2011年
永尾武難病研究基金 授与
2012年
公益財団法人 武田科学振興財団 医学系研究奨励金 授与
2012年
先進医薬研究振興財団 血液医学分野一般研究助成金 授与
2014年
日本リウマチ財団 リウマチ性疾患調査・研究助成金 授与
原著論文
Takahashi R., Nakatsukasa H, Shiozawa, S, Yoshimura A.
SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions.
J Immunol. 2017;199:149-158
Takahashi R., Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Asakawa M, Chinen T, Yoshimura A.
SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production.
J Exp Med. 2011;208:2055-67.
Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R., Yoshimura A.
Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin.
Immunity. 2011;34:741-54.
Hashimoto M, Hiwatashi K, Ichiyama K, Morita R, Sekiya T, Kimura A, Sugiyama Y, Sibata T, Kuroda K, Takahashi R., Yoshimura A.
SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling.
Int Immunol. 2011;23:165-76.
Takimoto T, Wakabayashi Y, Sekiya T, Inoue N, Morita R, Ichiyama K, Takahashi R., Asakawa M, Muto G, Mori T, Hasegawa E, Saika S, Hara T, Nomura M, Yoshimura A.
Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.
J Immunol. 2010;185:842-55.
Oka Y, Kameoka J, Hirabayashi Y, Takahashi R., Ishii T, Sasaki T, Harigae H.
Reversible bone marrow dysplasia in patients with systemic lupus erythematosus.
Intern Med. 2008;47:737-42.
Hirabayashi Y, Oka Y, Tada M, Takahashi R., Ishii T.
A potential trigger of nephritogenic anti-DNA antibodies in lupus nephritis.
Ann N Y Acad Sci. 2007;1108:92-5.
Oka Y, Hirabayashi Y, Ishii T, Takahashi R., Sasaki T.
A monoclonal antibody against human homocysteine-induced endoplasmic reticulum protein (Herp): a useful tool for evaluating endoplasmic reticulum stress.
Tohoku J Exp Med. 2007;212:431-7.
Takahashi R., Tsutsumi A, Ohtani K, Wakamiya N, Sumida T.
Lack of relationship between mannose-binding lectin variant alleles and risk of arterial thrombosis in Japanese patients with systemic lupus erythematosus.
Mod Rheumatol. 2005;15:459-60.
Hayashi T, Matsumoto I, Muraki Y, Takahashi R., Chino Y, Goto D, Ito S, Tsutsumi A, Sumida T.
Clinical characteristics of anti-glucose-6-phosphate isomerase antibodies positive Japanese patients with rheumatoid arthritis.
Modern Rheumatol. 2005;15:258-63.
Takahashi R., Tsutsumi A, Ohtani K, Muraki Y, Goto D, Matsumoto I, Wakamiya N, Sumida T.
Association of mannnose-binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus.
Ann Rheum Dis. 2005;64:311-4.
Takahashi R., Endoh M.
Dual regulation of myofilament Ca2+ sensitivity by levosimendan in normal and acidotic conditions in aequorin-loaded canine ventricular myocardium.
Br J Pharmacol. 2005;145:1143-52.
Takahashi R., Tsutsumi A, Ohtani K, Goto D, Matsumoto I, Ito S, Wakamiya N, Sumida T.
Anti-mannose binding lectin antibodies in sera of Japanese patients with systemic lupus erythematosus.
Clin Exp Immunol. 2004;136:585-90.
Muraki Y, Tsutsumi A, Takahashi R., Suzuki E, Hayashi T, Chino Y, Goto D, Matsumoto I, Murata H, Noguchi E, and Sumida T.
Polymorphisms of IL-1β gene in Japanese patients with Sjogren’s syndrome and systemic lupus erythematosus.
J. Rheumatol. 2004;31:720-5.
Tsutsumi A, Ikegami H, Takahashi R., Murata H, Goto D, Matsumoto I, Fujisawa T, Sumida T.
Mannose binding lectin gene polymorphism in patients with type I diabetes.
Hum Immunol. 2003;64:621-4.
Chu L, Takahashi R., Norota I, Miyamoto T, Takeishi Y, Ishii K, Kubota I, Endoh M.
Signal transduction and Ca2+ signaling in the regulation of contraction induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium.
Circ Res. 2003;16:1024-32.
Takahashi R., Endoh M.
Effects of OR-1896, a metabolite of levosimendan, under acidotic condition in aequorin-loaded canine ventricular myocardium.
Naunyn Schmiedebergs Arch Pharmacol. 2002;366:440-8.
Takahashi R., Shimazaki Y, Endoh M.
Decrease in Ca2+-sensitizing effect of UD-CG 212 Cl, a metabolite of pimobendan, under acidotic condition in canine ventricular myocardium.
J Pharmacol Exp Ther. 2001;298:1060-6.
Takahashi R., Endoh M.
Increase in myofibrillar Ca2+ sensitivity induced by UD-CG 212 Cl, an active metabolite of pimobendan, in canine ventricular myocardium.
J Cardiovasc Pharmacol. 2000;37:209-18.
Takahashi R., Endoh M.
Inotropic effects of OR-1896, an active metabolite of levosimendan, on canine ventricular myocardium.
Eur J Pharmacol. 2000;14:103-12.
Takahashi R., Endoh M.
Effects of OR-1896, an active metabolite of levosimendan, on contractile force and aequorin light transients in intact rabbit ventricular myocardium.
J Cardiovasc Pharmacol. 2000;36:118-25.
総説
Takahashi R., Yoshimura A.
SOCS1 and regulation of regulatory T cells plasticity.
J Immunol Res. 2014;2014:943149.
Tamiya T, Kashiwagi I, Takahashi R., Yasukawa H, Yoshimura A.
Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways: Regulation of T-Cell Inflammation by SOCS1 and SOCS3.
Arterioscler Thromb Vasc Biol. 2011;31:980-5.
Tsutsumi A, Takahashi R., Sumida T.
Mannose Binding Lectin: Genetics and Autoimmune Disease.
Autoimmun Rev. 2005;4:475-8.
症例報告
Nakanishi T, Horikoshi H, Kusanagi Y, Yamamura T, Takahashi R., Kimura F, Itoh K. Refractory dermatomyositis complicated with myelodysplastic syndrome.
Intern Med. 2015;54:2507-11.
Shirai T, Takahashi R., Tajima Y, Fujii H, Takasawa N, Ichinohasama R, Ishii T, Harigae H.
Suppression of Peripheral T cell lymphoma with high titer of proteinase-3-antineutrophil cytoplasmic antibodies that resembled Wegener’s granulomatosis.
Intern Med. 2009;48:2041-5.
Miyahara S, Ito S, Soeda A, Chino Y, Hayashi T, Takahashi R., Goto D, Matsumoto I, Tsutsumi A, Sumida T.
Two cases of systemic lupus erythematosus complicated with colonic ulcers.
Intern Med. 2005;12:1298-1306.
Murata H, Adachi Y, Ebitsuka T, Chino Y, Takahashi R., Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Akama H, and Sumida T.
Reiter's syndrome following intravesical Bacille bilie de Calmette-Guerin treatment for superficial bladder carcinoma. Report of six cases.
Modern. Rheumatol. 2004;14:82-6.
Adachi Y, Tsutsumi A, Murata H, Takemura H, Chino Y, Takahashi R., Ebitsuka T, Sumida T.
Behcet's disease accompanied by myelodysplastic syndrome with trisomy 8: Two case reports and review of 15 Japanese cases.
Modern Rheumatol. 2003;13:90-4.
Sugimoto T, Yamagiwa I, Obata K, Ouchi T, Takahashi R., Suzuki R, Shimazaki Y.
Choledochal cyst and duodenal atresia: a rare combination.
Pediatr Surg Int. 2002;18:281-3.

内科医師 兼 主任研究員
理化学研究所生体システム研究センター 客員研究員

山口 智之

研究テーマ:
免疫制御機構の解明と腫瘍免疫への応用

学位・資格
1997年
東京大学 医学部医学科卒業 医籍登録
2003年
東京大学大学院 内科学専攻博士課程修了 医学博士
職歴
1997年
東京大学医学部付属病院内科
1998年
国立国際医療センター
2003-2011年
京都大学 再生医学研究所 (生体機能調節学分野、坂口志文研究室)
2003年
理化学研究所 研究員
2005年
京都大学再生医科学研究所 COE研究員
2007年
京都大学再生医科学研究所 特任助教
2008年
京都大学再生医科学研究所 助教
2011-2017年
大阪大学 免疫学フロンティア研究センター
2011年
大阪大学免疫学フロンティア研究センター (実験免疫、坂口志文研究室) 特任准教授
2012年
大阪大学免疫学フロンティア研究センター (1細胞1分子イメージング、柳田敏雄研究室)特任准教授
2013年
理化学研究所 生体システム研究センター 客員研究員(兼任)
2017年
野崎徳洲会病院付属研究所 医師兼研究員
所属学会
日本免疫学会
日本生物物理学会
主要論文
Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata, UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses. Arterioscler Thromb Vasc Biol, 2017. 37(1): p. 66-74.
Matsumoto, T., N. Sasaki, T. Yamashita, T. Emoto, K. Kasahara, T. Mizoguchi, T. Hayashi, K. Yodoi, N. Kitano, T. Saito, T. Yamaguchi, and K. Hirata, Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol, 2016. 36(6): p. 1141-51.
Ichimura, T., L.D. Chiu, K. Fujita, H. Machiyama, T. Yamaguchi, T.M. Watanabe, and H. Fujita, Non-label immune cell state prediction using Raman spectroscopy. Sci Rep, 2016. 6: p. 37562.
Furusawa, C. and T. Yamaguchi, Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression. PLoS One, 2016. 11(9): p. e0163134.
Machiyama, H., T. Yamaguchi, Y. Sawada, T.M. Watanabe, and H. Fujita, SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane. FEBS J, 2015. 282(20): p. 4034-55.
Yamaguchi, T., A. Kishi, M. Osaki, H. Morikawa, P. Prieto-Martin, K. Wing, T. Saito, and S. Sakaguchi, Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression. Proc Natl Acad Sci U S A, 2013. 110(23): p. E2116-25.
Iyer, S.S., D.R. Latner, M.J. Zilliox, M. McCausland, R.S. Akondy, P. Penaloza-Macmaster, J.S. Hale, L. Ye, A.U. Mohammed, T. Yamaguchi, S. Sakaguchi, R.R. Amara, and R. Ahmed, Identification of novel markers for mouse CD4(+) T follicular helper cells. Eur J Immunol, 2013. 43(12): p. 3219-32.
Kinoshita, M., H. Kayama, T. Kusu, T. Yamaguchi, J. Kunisawa, H. Kiyono, S. Sakaguchi, and K. Takeda, Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol, 2012. 189(6): p. 2869-78.
Yamaguchi, T., J.B. Wing, and S. Sakaguchi, Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol, 2011. 23(6): p. 424-30.
Wing, K., T. Yamaguchi, and S. Sakaguchi, Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation. Trends Immunol, 2011. 32(9): p. 428-33.
Satou, Y., J. Yasunaga, T. Zhao, M. Yoshida, P. Miyazato, K. Takai, K. Shimizu, K. Ohshima, P.L. Green, N. Ohkura, T. Yamaguchi, M. Ono, S. Sakaguchi, and M. Matsuoka, HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog, 2011. 7(2): p. e1001274.
Teng, M.W., J.B. Swann, B. von Scheidt, J. Sharkey, N. Zerafa, N. McLaughlin, T. Yamaguchi, S. Sakaguchi, P.K. Darcy, and M.J. Smyth, Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion. Cancer Res, 2010. 70(7): p. 2665-74.
Sakaguchi, S., K. Wing, and T. Yamaguchi, Dynamics of peripheral tolerance and immune regulation mediated by Treg. Eur J Immunol, 2009. 39(9): p. 2331-6.
Sakaguchi, S., K. Wing, Y. Onishi, P. Prieto-Martin, and T. Yamaguchi, Regulatory T cells: how do they suppress immune responses? Int Immunol, 2009. 21(10): p. 1105-11.
Nagahama, K., Z. Fehervari, T. Oida, T. Yamaguchi, O. Ogawa, and S. Sakaguchi, Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. Int Immunol, 2009. 21(4): p. 379-91.
Miyara, M., Y. Yoshioka, A. Kitoh, T. Shima, K. Wing, A. Niwa, C. Parizot, C. Taflin, T. Heike, D. Valeyre, A. Mathian, T. Nakahata, T. Yamaguchi, T. Nomura, M. Ono, Z. Amoura, G. Gorochov, and S. Sakaguchi, Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity, 2009. 30(6): p. 899-911.
Kitoh, A., M. Ono, Y. Naoe, N. Ohkura, T. Yamaguchi, H. Yaguchi, I. Kitabayashi, T. Tsukada, T. Nomura, Y. Miyachi, I. Taniuchi, and S. Sakaguchi, Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity, 2009. 31(4): p. 609-20.
Wing, K., Y. Onishi, P. Prieto-Martin, T. Yamaguchi, M. Miyara, Z. Fehervari, T. Nomura, and S. Sakaguchi, CTLA-4 control over Foxp3+ regulatory T cell function. Science, 2008. 322(5899): p. 271-5.
Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono, Regulatory T cells and immune tolerance. Cell, 2008. 133(5): p. 775-87.
Onishi, Y., Z. Fehervari, T. Yamaguchi, and S. Sakaguchi, Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A, 2008. 105(29): p. 10113-8.
Yamaguchi, T., K. Hirota, K. Nagahama, K. Ohkawa, T. Takahashi, T. Nomura, and S. Sakaguchi, Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity, 2007. 27(1): p. 145-59.
Hirota, K., H. Yoshitomi, M. Hashimoto, S. Maeda, S. Teradaira, N. Sugimoto, T. Yamaguchi, T. Nomura, H. Ito, T. Nakamura, N. Sakaguchi, and S. Sakaguchi, Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med, 2007. 204(12): p. 2803-12.
Hirota, K., M. Hashimoto, H. Yoshitomi, S. Tanaka, T. Nomura, T. Yamaguchi, Y. Iwakura, N. Sakaguchi, and S. Sakaguchi, T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med, 2007. 204(1): p. 41-7.
Yamaguchi, T. and S. Sakaguchi, Regulatory T cells in immune surveillance and treatment of cancer. Semin Cancer Biol, 2006. 16(2): p. 115-23.
Yamaguchi, T. and S. Sakaguchi, Skin controls immune regulators. Nat Med, 2006. 12(12): p. 1358-9.
Fehervari, Z., T. Yamaguchi, and S. Sakaguchi, The dichotomous role of IL-2: tolerance versus immunity. Trends Immunol, 2006. 27(3): p. 109-11.
Ko, K., S. Yamazaki, K. Nakamura, T. Nishioka, K. Hirota, T. Yamaguchi, J. Shimizu, T. Nomura, T. Chiba, and S. Sakaguchi, Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med, 2005. 202(7): p. 885-91.
Kunisato, A., S. Chiba, T. Saito, K. Kumano, E. Nakagami-Yamaguchi, T. Yamaguchi, and H. Hirai, Stem cell leukemia protein directs hematopoietic stem cell fate. Blood, 2004. 103(9): p. 3336-41.
Saito, T., S. Chiba, M. Ichikawa, A. Kunisato, T. Asai, K. Shimizu, T. Yamaguchi, G. Yamamoto, S. Seo, K. Kumano, E. Nakagami-Yamaguchi, Y. Hamada, S. Aizawa, and H. Hirai, Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity, 2003. 18(5): p. 675-85.
Kunisato, A., S. Chiba, E. Nakagami-Yamaguchi, K. Kumano, T. Saito, S. Masuda, T. Yamaguchi, M. Osawa, R. Kageyama, H. Nakauchi, M. Nishikawa, and H. Hirai, HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood, 2003. 101(5): p. 1777-83.
Kumano, K., S. Chiba, A. Kunisato, M. Sata, T. Saito, E. Nakagami-Yamaguchi, T. Yamaguchi, S. Masuda, K. Shimizu, T. Takahashi, S. Ogawa, Y. Hamada, and H. Hirai, Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Immunity, 2003. 18(5): p. 699-711.