スタッフ紹介

再生医学研究部門
部長(主任研究員)

品川 敏恵

研究テーマ:
1. 幹細胞と組織再生機構
2. ヒトと細菌の共生関係と感染症

学位・資格
1998年
岐阜大学大学院連合獣医学研究科修了、博士(獣医学)
獣医師
主な職歴
1996年
日本学術振興会 特別研究員DC1
1998年
理化学研究所 協力研究員
2001年
同  基礎科学特別研究員
2004年
同  特定協力研究員
2005年
同  研究員(スタッフ)
2008-2018年
同  専任研究員(スタッフ)
2012-2017年
筑波大学連携大学院医学医療系 准教授(兼任) 
2018年
野崎徳州会病院附属研究所 部長
所属学会
日本分子生物学会
主要論文
Ikeda T*, Shinagawa T, Ito T, Ohno Y, Kubo A, Nishi J, Gotoh Y, Ogura Y, Ooka T, Hayashi T. Hypoosmotic stress induces flagellar biosynthesis and swimming motility in Escherichia albertiiCommus Biol. 3(1), 87, 2020 doi: 10.1038/s42003-020-0816-5.
https://www.nature.com/articles/s42003-020-0816-5
Padavattan S, Thiruselvam V, Shinagawa T, Hasegawa K, Kumasaka T, Ishii S and Kumarevel T
Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b
Biophys Chem. 221, 41-48, 2017
Huynh LM, Shinagawa T* and Ishii S.*
Two histone variants TH2A and TH2B enhance human iPS cell generation.
Stem Cells Dev. 25, 251-258, 2016 (*: 責任著者)
Padavattan S, Shinagawa T, Hasegawa K, Kumasaka T, Ishii S and Kumarevel T Structural and functional analyses of nucleosome complexes with mouse histone variants TH2a and TH2b, involved in reprogramming.
Biochem. Biophys. Res. Commun. 464, 929–935, 2015
Shinagawa T*, Huynh LM, Takagi T, Tsukamoto D, Tomaru C, Kwak H, Dohmae N, Noguchi J and Ishii S.* Disruption of Th2a and Th2b genes causes defects in spermatogenesis.
Development 142, 1287–1292, 2015 (*: 責任著者)
Shinagawa T*, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K and Ishii S.* Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.
Cell Stem Cell 14; 217–227, 2014 (*: 責任著者)
この論文はF1000Primeに選ばれました
Zaman MM, Shinagawa T and Ishii S.
Trim27-deficient mice are susceptible to streptozotocin-induced diabetes.
FEBS Open Bio 4; 60–64, 2013
Zaman MM, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, Tanaka Y and Ishii S. Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis.
Mol. Cell. Biol. 33; 4971–4984, 2013
Hirose N, Maekawa T, Shinagawa Tand Ishii S. ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells.
Biochem. Biophys. Res. Commun. 385; 72–77, 2009
Yamauchi T, Ishidao T, Nomura T, Shinagawa T, Tanaka Y, Yonemura S and Ishii S. A B-Myb complex containing clathrin and filamin is required for mitotic spindle function.
EMBO J. 27; 1852–1862, 2008
Shimada N., Shinagawa T and Ishii S.
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.
Genes Cells 13; 245–254, 2008
Maekawa T, Sano Y, Shinagawa T, Rahman Z, Sakuma T, Nomura S, Licht JD and Ishii S. ATF-2 controls transcription of Maspin and GADD45 alpha genes independently from p53 to suppress mammary tumors.
Oncogene 27; 1045–1054, 2008
Maekawa T, Shinagawa T, Sano Y, Sakuma T, Nomura S, Nagasaki K, Miki Y, Saito-Ohara F, Inazawa J, Kohno T, Yokota J and Ishii S. Reduced levels of ATF-2 predispose mice to mammary tumors.
Mol. Cell. Biol. 27; 1730–1744, 2007
Makino C, Sano Y, Shinagawa T, Millar JBA and Ishii S. Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.
Genes Cells 11; 1239–1251, 2006
14. Tanikawa J, Nomura T, Macmillan EM, Shinagawa T, Jin W, Kokura K, Baba D, Shirakawa M, Gonda TJ and Ishii S. p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A.
J. Biol. Chem. 279; 55393–55400, 2004
Shinagawa T and Ishii S.
Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter.
Genes Dev. 17; 1340–1345, 2003
この論文はF1000に選ばれました。
Kokura K, Kim H, Shinagawa T, Khan MM, Nomura T and Ishii S. The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm.
J. Biol. Chem. 278; 20133–20139, 2003
Dai P*, Shinagawa T*, Nomura T, Harada J, Kaul SC, Wadhwa R, Khan MM, Akimaru H, Sasaki H, Colmenares C. and Ishii S. Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.
Genes Dev. 16; 2843–2848, 2002 (*: These authors are equally contributed.)
Shinagawa T, Nomura T, Colmenares C, Ohira M, Nakagawara A and Ishii S. Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice.
Oncogene 20; 8100–8108, 2001
Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T, Yasukawa T, Colmenares C and Ishii S. The Ski protein family is required for MeCP2-mediated transcriptional repression.
J. Biol. Chem. 276; 34115–34121, 2001
Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP and Ishii S. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.
Mol. Cell 7; 1233–1243, 2001
Shinagawa T, Dong HD, Xu M, Maekawa T and Ishii S. The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice.
EMBO J. 19; 2280–2291, 2000
Shinagawa T, Ishiguro N, Horiuchi M and Shinagawa M. Instability of the 12-nucleotide repeat in c-myb gene of bovine T-lymphoma cells.
J. Vet. Med. Sci. 59; 1071–1074, 1997
Shinagawa T, Ishiguro N, Horiuchi M, Matsui T, Okada K and Shinagawa M. Deletion of c-myb exon 9 induced by insertion of repeats.
Oncogene 14; 2775–2783, 1997
Shinagawa T, Nunoi H, Nonoyama S and Kanegasaki S. Induction of CD40 in promyelocytic HL60 cells cultured with retinoic acid and/or various cytokines.
J. Biochem. 11; 534–540, 1995
Shinagawa T, Ishiguro N, Horiuchi M and Shinagawa M. Monoclonal antibody S37 induces apoptosis in bovine T lymphoma cells.
J. Vet. Med. Sci. 56; 957–959, 1994
Shinagawa T, Ishiguro N, Horiuchi M, Shinagawa M. and Matsui T Characterization of monoclonal antibodies against sporadic bovine leukosis cell lines.
J. Vet. Med. Sci. 56; 827–833, 1994
Ishiguro N, Ohzono T, Shinagawa T, Horiuchi M and Shinagawa M. A spontaneous internal deletion of the c-myb protooncogene enhances transcriptional activation in bovine T lymphoma cells.
J. Biol. Chem. 269; 26822–26829, 1994
Ishiguro N, Shinagawa T, Matsui T and Shinagawa M. Putative bovine B cell lineage tumor in sporadic bovine leukosis.
Vet. Immunol. Immunopathol. 42; 185–197, 1994
Ishiguro N, Aida Y, Shinagawa T and Shinagawa M. Molecular structures of cattle T-cell receptor gamma and delta chains predominantly expressed on peripheral blood lymphocytes.
Immunogenetics 38; 437–443, 1993
特許取得
【発行国】
米国
【発明の名称】
Nuclear reprogrammed cells generated by introduction of a histone H2AA or TH2A gene, a histone H2BA or TH2B gene, or a phosphorylation-mimic of histone chaperon NPM2 gene, an Oct family gene and a KLF gene into a mammalian somatic cells.
【出願日】
2012/8/29
【米国特許番号】
US 9,145,547 B2
【発明者】
Shinagawa; Toshie (Wako, JP), Ishii; Shunsuke (Wako, JP)