研究員

伊藤 和幸

研究テーマ：細胞内シグナル伝達系による生体の機能調節と臨床への応用

履歴

1983年 3月

山口大学医学部卒業　(医籍登録278798、83-6-28)

1987年 3月

大阪大学医学部大学院修了　医学博士 (阪大医7640、87-3-26)

1987年 4月

大阪大学医学部第４内科

1989年 2月

大阪府立成人病センター研究所

1992年 7月

米国国立予防衛生研究所 (NIH) Visiting Associate

1995年10月

大阪府立成人病センター研究所

2001年 4月

大阪府立成人病センター研究所生物学部門長

2010年 4月

大阪府立大学大学院生命環境科学研究科客員教授~2013.3

2011年 4月

大阪府立成人病センター研究所病理学部門長（兼任）~2014.9

2011年 4月

信州大学大学院医学系　研究科　客員教授~2014.3．

2016年 4月

野崎徳州会病院　研究所長、内科部長

受賞等

1992年 4月

1992年度日本心臓財団海外留学助成

1999年 5月

第3回がん転移学会奨励賞

1999年11月

第38回ベルツ賞

委員等

文部科学省　科学研究費補助金専門委員

学会

日本がん転移学会（前会長、事務局幹事）

国際転移学会(Board of Directors(理事))

日本癌学会（評議員）

日本生化学会

日本心血管内分泌代謝学会

米国細胞生物学会

Editorial Board: Clinical and Experimental Metastasis, Journal of Orthopedic Science

主要発表論文

Itoh, K. and Adelstein, R. S.: Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B: J. Biol. Chem. 270: 14533-14540 (1995)

Rochlin, M. W., Itoh, K., Adelstein, R. S. and Bridgeman P. C.: Localization of myosin II A and B isoforms in cultured neurons: J. Cell Sci. 108: 3661-3670 (1995)

Yoshioka, K, Matsumura, F., Akedo, H. and Itoh, K.: Small GTP-binding Protein Rho Simulates the Actomyosin System, Leading to Invasion of Tumor Cells: J. Biol. Chem. 273: 5146-5154 (1998)

Asai, T., Ueda, T., Itoh, K., Yoshioka, K., Aoki, Y., Mori S. and Yoshikawa H.: Establishment and characterization of a murine osteosarcoma (LM8) with high metastatic potential to the lung: Int. J. Cancer 76: 418-422 (1998)

Itoh, K., Yoshioka, K., Akedo, H., Uehata, M., Ishizaki, T. and Narumiya, S.: An essential part for Rho-associated kinase in the transcellular invasion of tumor cells: Nature Medicine 5: 221-225 (1999)

Yoshioka, K., Nakamori, S. and Itoh, K.: Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells: Cancer Research 59: 2004-2010 (1999)

Itoh, K. and Yoshioka, K.: Molecules that allow tumor cells to invade new tissues: ASCB Press Book : 4-5 (1999)

Manzanares, MV., Cabrero JR., Rey, M., Martínez, MP., Ursa, A., Itoh, K.and Madrid, FS.:A role for the Rho-p160Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1-induced lymphocyte actomyosin and microtubular organization and chemotaxis: J. Immunology 168: 400-410 (2002)

Naka, M., Araki, N., Nakanishi, H., Itoh, K., Mano, M., Ishiguro, S., Brujin, DR., Myoui, A., Ueda, T. and Yoshikawa, K.: Expression of SSX genes in human osteosarcomas: Int. J. Cancer 98: 640-642 (2002)

Higuchi, C., Myoui, A., Hashimoto, N., Kuriyama, K., Yoshioka, K., Yoshikawa, H. and Itoh, K.: Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of extracellular matrix: J. Bone Miner. Res.17: 1785-1794 (2002)

Kuriyama, K., Higuchi, C., Tanaka, K., Yoshikawa, H. and Itoh, K.: A novel anti-rheumatic drug, T-614, stimulates osteoblastic differentiation in vitro and bone morphogenetic protein-2 induced bone formation in vivoBiochem. Biophys. Res. Commun.299: 903-909 (2002)

Manzanares, MV., Rey, M., Martínez, MP., Mo, MY, Sancho, D., Cabrero JR., Barreiro, O., Fuente, H., Itoh, K. and Madrid, FS.: The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes: J. Immunology 171: 1023-1034 (2003)

Yoshioka, K., Foletta, V., Bernard, O. and Itoh, K.: A Role for LIM-Kinase in Cancer Invasion: Proc. Natl. Acad. Sci. USA. 100: 7247-7252 (2003)

Nishimura, Y., Itoh, K., Yoshioka, K., Tokuda, K. and Himeno, M.: Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes: Pathology Oncology Res. 9:83-95 (2003)

Nakanishi, H., Yoshioka, K., Joyama, S., Araki, N., Myoui, A., Ishiguro, S., Ueda, T., Yoshikawa, H., and Itoh, K.: IL-6/soluble IL-6R Signaling Attenuates Proliferation and Invasion, and Induces Morphological Changes of a Newly Established Pleomorphic Malignant Fibrous Histiocytoma Cell Line: Am. J. Pathol. 165: 471-480 (2004)

Itoh, K., Joyama, S., Naka, N., and Yoshioka, K.: SSX: new molecular target regulating cancer cell invasion: Clin. Exp. Metastasis. 21:617 (2004)

Naka, N., Joyama, S., Tsukamoto, Y., Yoshioka, K., Hashimoto, H., Ujiiye T., Hayashi, T., Kawase, M., Mano, M., Ishiguro, S., Myoui, A., Ueda, T., Yoshikawa, H., Araki, N., and Itoh, K.: Quantification of SSX mRNA expression in human bone and soft tissue tumors using Nucleic Acid Sequence-Based Amplification (NASBA): J. Mol. Diagn. 7:187-197 (2005)

Nakagawa, H., Yoshioka, K., Miyahara, E., Fukushima, Y., Tamura, M., and Itoh, K.: Intrathecal administration of Y-27632, a specific ROCK inhibitor, for rat neoplastic meningitis: Mol. Cancer Res., 3: 425-433, cited on the cover (2005)

Zhang, X., Lin, M., van Golen, KL, Yoshioka. K., Itoh K., and Yee, D.: Multiple signaling pathways are activated during Insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration: Breast Cancer Res Treat., 93: 159-168 (2005)

Jomgeow, T., Oji, Y., Tsuji, N., Ikeda, Y., Ito, K., Tsuda, A., Nakazawa, T., Tatsumi, N, Sakaguchi, N., Takashima, S., Shirakata, T., Nishida, S., Hosen, N., Kawakami, M., Tsuboi, A., Oka, Y., Itoh, K., and Sugiyama, H.: Wilms’ tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion: Cancer Sci. 97: 259-270 (2006)

Joyama, S., Naka, N., Tsukamoto, Y., Yoshikawa, H., and Itoh, K.: Dendritic Cell Immunotherapy for Lung Metastasis from Murine Osteosarcoma: Clin. Orthop. Relat. Res. 453: 318-327 (2006)

Sotobori, T., Ueda, T., Myoui, A., Yoshioka, K., Nakasaki, M., Yoshikawa, H., and Itoh, K.: Bone morphogenetic protein-2 promotes the haptotactic migration of murine osteoblastic and osteosarcoma cells by enhancing incorporation of integrin 1 into lipid rafts: Exp. Cell Res. 312:3927-3938 (2006)

Fukushima, Y., Tamura, M., Nakagawa, H., and Itoh, K.: Induction of glioma cell migration by Vitronectin in human serum and cerebrospinal fluid:J. Neurosurg. 107: 578-585 (2007)

Yamate, J., Ogata, K., Yuasa, T., Kuwamura, M., Takenaka, S., Kumagai, D., Itoh K., and LaMarre., J.; Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells: Eur J. Cancer 43:2747-2756 (2007)

Nishimura, Y., Yoshioka, K., Bereczky, B., and Itoh, K.: Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line: Mol Cancer 7:42 (2008)

Baba, M., Inoue, M., Itoh, K. and Nishizawa, Y.: Blocking CD147 induces cell death through impairment of glycolytic energy metabolism: Biochem. Biophys. Res. Commun. 374: 111-116 (2008)

Nakasaki, M., Yoshioka, K., Miyamoto, Y., Sasaki T., Yoshikawa, H., and Itoh, K.: IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts: Bone 43:869-879 (2008)

Steeg, PS., Anderson, RL., Bar-Eli, M., Chambers, AF., Eccles, SA., Hunter, K., Itoh, K., Kang Y., Matrisian LM., Sleeman JP., Theodorescu D., Thompson EW., and Welch, DR.: Preclinical drug development must consider the impact on metastasis: Clin. Cancer Research 15:4529-4530 (2009)

Yoshikawa, H., Yoshioka, K., Nakase, T., and Itoh, K.: Stimulation of Ectopic Bone Formation in Response to BMP-2 by Rho-associated Kinase Inhibitor-A pilot study: Clin. Orthop. Relat. Res. 467:3087-3095 (2009)

Takenaka, S., Naka, N., Araki, N., Hashimoto, N., Ueda, T., Yoshioka, K., Yoshikawa, H. and Itoh, K.: Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo: Int J Oncology 36:823-831 (2010)

Naka, N., Takenaka, S., Araki, N., Miwa, T., Hashimoto, N., Yoshioka, K., Joyama, S., Hamada, K., Tsukamoto, Y., Tomita, Y., Ueda, T., Yoshikawa, H., and Itoh K.: Synovial sarcoma is a stem cell malignancy: Stem Cells 28:1119-1131 (2010)

Yui, Y., Itoh, K., Yoshioka, K., Naka, N., Watanabe, M., Hiraumi, Y., Matsubara, H., Watanabe, K., Sano, K., Nakahata, T. and Adachi S.: Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8: Clin Exp Metastasis 27: 619-630 (2010)

Sonoshita, M., Aoki, M., Fuwa, H., Aoki K., Hosogi, H., Sakai, Y., Hashida, H., Takabayashi, A., Sasaki, M., Robine, S., Itoh, K., Yoshioka, K., Kakizaki, F., Kitamura, T., Oshima, M. and Taketo. M. M.: Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling: Cancer Cell 19: 125-137 (2011)

Ichida, M., Yui Y., Yoshioka K., Tanaka T., Wakamatsu T., Yoshikawa H. and Itoh K.: Changes in cell migration of mesenchymal cells during osteogenic differentiation: FEBS Letters: 585: 4018-4024 (2011)

Tanaka, T., Yui, Y., Naka, N., Wakamatsu, T., Yoshioka, K., Araki, N., Yoshikawa, H. and Itoh, K.: Dynamic analysis of lung metastasis by mouse osteosarcoma LM8-VEGF is a candidate for anti-metastasis therapy: Clin Exp Metastasis30: 369-379 (2013)

Nishimura, Y., Takiguchi, S., Ito, S. and Itoh, K.: Evidence that depletion of the sorting nexin 1 by siRNA promotes HGF-induced MET endocytosis and MET phosphorylation in a gefitinib-resistant human lung cancer cell line：Int J Oncology 44: 412-426 (2014)

Yasui, H., Naka, N., Imura, Y., Outani, H., Kaneko, K., Hamada, K., Sasagawa, S., Araki, N., Ueda, T., Itoh, K., Myoui, A. and Yoshikawa, H.: Tailored therapeutic strategies for synovial sarcoma: Receptor tyrosine kinase pathway analyses predict sensitivity to the mTOR inhibitor RAD001: Cancer lett 347:114-122 (2014)

Outani, H., Tanaka, T., Wakamatsu, T., Imura, Y., Hamada, K., Araki, N., Itoh, K., Yoshikawa, H. and Naka, N.: Establishment of Hewga-clear cell sarcoma, a new clear cell sarcoma cell line, and investigation of the antitumor effects of pazopanib on Hewga-CCS: an in vitro and in vivo study: BMC Cancer: 14:455 (2014)

Wakamatsu, T., Naka, N., Sasagawa, S., Tanaka, T., Takenaka, S., Araki, N., Ueda, T., Yoshioka, K., Nishizawa, Y., Yoshikawa, H. and Itoh, K.: Deflection of VEGF action by SS18-SSX and composite VEGF- and CXCR4-targeted therapy in synovial sarcoma: Cancer Science: 105: 1124-1134 (2014)

Imura, Y., Yasui, H., Outani, H., Wakamatsu, T., Hamada, K., Nakai, T., Yamada, S., Myoui, A,, Araki, N., Ueda, T., Itoh, K., Yoshikawa, H., and Naka, N.: Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma: Mol Cancer 13(1):185 (2014)

Itoh, K.: Basic Research for Osteosarcoma Lung Metastasis (LM8): chapter 18 in “Osteosarcoma” edited by Drs. Ueda, T. and Kawai, A. by Springer (2014)

Nishimura, Y., Takiguchi, S., Ito, S. and Itoh, K.: EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line：Int J Oncology 46: 1721-1729 (2015)

Yasui, H., Imura, Y., Outani, H., Hamada, K., Nakai, T., Yamada, S., Takenaka, S., Sasagawa, S., Araki, N., Itoh, K., Myoui, A., Yoshikawa, H. and Naka, N.: Trabectedin is a Promising Anti-tumor Agent for Synovial Sarcoma: Journal of Chemotherapy: Jan 29: 1-8 (2016)

Fukuda, H., Chisaki, Y., Takada, T., Toda, Y., Murata, H., Itoh, K., Yano, Y., Takata, K., and Ashihara, E.: Daphnetin Inhibits Invasion and Migration of LM8 Murine Osteosarcoma Cells by Decreasing RhoA and Cdc42 Expression: Biochem. Biophys. Res. Commun. : 471:63-67 (2016)

Nishimura, Y., Hyuga, S., Takiguchi, S., Hyuga, M., Itoh, K. and Hanawa, T.: Ephedrae stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathway in a gefitinib-resistant human lung cancer cell line：Int J Oncology: 48:1895-1906 (2016)

Imura, Y., Nakai, T., Yamada, S., Outani. H., Takenaka. S., Hamada, K., Araki, N., Itoh, K., Yoshikawa, H., and Naka, N.: Functional and therapeutic relevance of hepatocyte growth factor/c-MET signaling in synovial sarcoma: Cancer Science: 107(12): 1867-1876 (2016)

Yamada, S., Imura, Y., Nakai, T., Nakai, S., Yasuda, N., Kaneko. K., Outani. H., Takenaka. S., Hamada, K., Myoui, A., Araki, N., Ueda, T., Itoh, K., Yoshikawa, H., and Naka, N : Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma: BMC Cancer in press (2017)

Nakai, T., Imura, Y., Tamiya., Yamada, S., Nakai, S., Yasuda, N., Kaneko, K., Outani, H., Takenaka, S., Hamada, K., Myoui, A., Araki, N., Ueda, T., Itoh, K., Yoshikawa, H., and Naka, N.: Trabectedin is a promising antitumor agent potentially inducing melanocytic differentiation for clear cell sarcoma: Cancer Medicine in press (2017)

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