所長

川市 正史

研究テーマ：
1.神経系の発生学、Notch とRBP-J、小脳の発生、小胞輸送と小脳性運動失調症の発症機構
2.分泌性セリンプロテアーゼHtrA1と変形性関節炎、網膜黄斑変性、遺伝性脳小動脈性痴呆（CARASIL）の発症機構

学位・資格

1975年

京都大学医学部医学科　卒業

1981年

京都大学医学博士

主要論文

HtrA1 meets NETs: does it open a new field?
Oka C, Kawaichi M.
Blood. 2021 Sep 16;138(11):920-921.

Diphtheria toxin-mediated transposon-driven poly (A)-trapping efficiently disrupts transcriptionally silent genes in embryonic stem cells.Bai J, Kondo R, Mayasari NI, Shigeoka T, Isotani A, Ikawa M, Sashida G, Kawaichi M, and Ishida Y.
Genesis. 2020 Sep;58(9):e23386.

Loss of HtrA1 serine protease induces synthetic modulation of aortic vascular smooth muscle cells.
Ikawati M, Kawaichi M, and Oka C.
PLoS One. 2018 May 16;13(5):e0196628.

CIBZ Regulates Mesodermal and Cardiac Differentiation of by Suppressing T and Mesp1 Expression in Mouse Embryonic Stem Cells.
Kotoku T, Kosaka K, Nishio M, Ishida Y, Kawaichi M, Matsuda E.
Sci Rep. 2016 Sep 23;6:34188.

Epigenetic silencing of serine protease HTRA1 drives polyploidy.
Schmidt N, Irle I, Ripkens K, Lux V, Nelles J, Johannes C, Parry L, Greenow K, Amir S, Campioni M, Baldi A, Oka C, Kawaichi M, Clarke AR, and Ehrmann M
BMC Cancer. 2016 Jul 7;16:399.

BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
Akamatsu R, Ishida-Kitagawa N, Aoyama T, Oka C, and Kawaichi M.
Genes Cells. 2015 Feb;20(2):135-52.

Abnormal development of placenta in HtrA1-deficient mice.
Hasan MZ, Ikawati M, Tocharus J, Kawaichi M, and Oka C.
Dev Biol. 2015 Jan 1;397(1):89-102.

HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway.Supanji, Shimomachi M, Hasan MZ, Kawaichi M, and Oka C.
Exp Eye Res. 2013 Jul;112:79-92.

Mixture of differentially tagged Tol2 transposons accelerates conditional disruption of a broad spectrum of genes in mouse embryonic stem cells.
Mayasari NI, Mukougawa K, Shigeoka T, Kawakami K, Kawaichi M, and Ishida Y.
Nucleic Acids Res. 2012 Jul;40(13):e97.

CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog.
Nishii T, Oikawa Y, Ishida Y, Kawaichi M, and Matsuda E.
J Biol Chem. 2012 Apr 6;287(15):12417-24.