悪性腫瘍新規治療法開発研究部
独立研究員

熊井　準

研究テーマ
細胞外マトリックス(ECM)が及ぼすがん悪性化メカニズムの解明

学位・資格

2013年

東京薬科大学薬学部卒業　薬剤師

2017年

東京薬科大学大学院　薬学研究科　修了　博士（薬学）

所属学会

日本薬学会

がん転移学会

主要論文

Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma. Sasagawa S.,Kumai J. , Wakamatsu T.,Yui Y. Cancer Inv., 2024. 3(2), e133.

Lung fibrosis is a novel therapeutic target to suppress lung metastasis of osteosarcoma. Yui Y., Kumai J. , Watanabe K., Wakamatsu T., Sasagawa S., Int. J. Cancer, 2022. doi.org/10.1002/ijc.34008.t

A Novel Method for Polyacrylamide Gel Preparation Using N-hydroxysuccinimide-acrylamide Ester to Study Cell-Extracellular Matrix Mechanical Interactions. Kumai J., Sasagawa S., Horie M., Yui Y., Front. Mater., 2021. doi.org/10.3389/fmats.2021.637278.

Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells. Igarashi, K., Yui, Y., Watanabe, K.,Kumai, J., Nishizawa, Y., Miyaura, C., Inada, M., Sasagawa, S. BMC Cancer. 20(1):802. 2020.

Identification of active sequences in human laminin α5 G domain. Kumai, J., Yamada, Y., Hamada, K., Katagiri, F., Hozumi, K., Kikkawa, Y., Nomizu, M. J. Pept. Sci., e3218, 2019.

Biological activity of peptide-conjugated polyion complex matrices consisting of alginate and chitosan. Fujimori, C‡., Kumai, J‡., Nakamura, K., Gu, Y., Hozumi, K., Katagiri, F., Kikkawa, Y., and Nomizu, M. Biopolymers, 108: e22983., 2017(‡These authors contributed equally to this work)

Effect of spacer length and type on the biological activity of peptide-polysaccharide matrices. Kumai, J., Hozumi, K., Yamada, Y., Katagiri, F., Kikkawa, Y., and Nomizu, M.* Biopolymers, 106: 512-20, 2016.