悪性腫瘍新規治療法開発研究部
部長

由井 理洋

研究テーマ：骨軟部腫瘍の転移メカニズム解明と抗転移療法の開発

学位・資格

2009年

京都大学大学院医学研究科発達小児科学 博士課程修了

2001年

京都大学医学部卒業

日本小児科学会専門医

所属学会

日本がん転移学会 (評議員)

日本癌学会

日本小児科学会

Yoshihiro Yui, Jun Kumai, Kenta Watanabe, Toru Wakamatsu, Satoru Sasagawa. Lung fibrosis is a novel therapeutic target to suppress lung metastasis of osteosarcoma. International Journal of Cancer, 2022, 151(5), 739-751.

Jun Kumai, Satoru Sasagawa, Masanobu Horie and Yoshihiro Yui. A Novel Method for Polyacrylamide Gel Preparation Using N-hydroxysuccinimide-acrylamide Ester to Study Cell-Extracellular Matrix Mechanical Interactions. Frontiers in Materials, Volume 8, Article number: 637378 (2021)

Ko Igarashi, Yoshihiro Yui, Kenta Watanabe, Jun Kumai, Yasuko Nishizawa, Chisato Miyaura, Masaki Inada & Satoru Sasagawa. Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells. BMC Cancer, Volume 20, Article number: 802 (2020)

Kenta Watanabe*, Yoshihiro Yui*, Satoru Sasagawa, Kayo Suzuki, Masahiko Kanamori, Taketoshi Yasuda and Tomoatsu Kimura (*These authors contributed equally to this work). Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget, 2019, Vol. 10, (No. 2), pp: 161-174

Nakagawa H., Yui Y., Sasagawa S., Itoh K. Evidence for intrathecal sodium butyrate as a novel option for leptomeningeal metastasis. Journal of Neuro-Oncology (2018)

Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nature Medicine. 2014, 20(4): 360-367.

Yui Y, Itoh K, Yoshioka K, Naka N, Watanabe M, Hiraumi Y, Matsubara H, Watanabe K, Sano K, Nakahata T, Adachi S. Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8. Clin. Exp. Metastasis. 2010; 27: 619-630