疾患機能ゲノミクス研究部　
主任研究員

圓岡　真宏

研究テーマ
全ライフステージにおけるシナプス除去のゲノム基盤

学位・資格

2009年3月

博士(バイオサイエンス)

所属学会

日本生化学会

日本分子生物学会

日本Cell Death学会

主要論文

H Niu, M Maruoka, Y Noguchi, H Kosako, J Suzuki. Phospholipid scrambling induced by an ion channel/metabolite transporter complex. Nature Communications 15(1) (2024)

Y Noguchi, Y Onodera, T Miyamoto, M Maruoka, H Kosako, J Suzuki. In vivo CRISPR screening directly targeting testicular cells. Cell Genomics 13;4(3) (2024)

P Zhang, M Maruoka, R Suzuki, H Katani, Y Dou, DM. Packwood, H Kosako, M Tanaka, J Suzuki. Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4. Nature Communications 14(1) (2023) 5592

M Maruoka, P Zhang, H Mori, E Imanishi, DM Packwood, H Harada, H Kosako, J Suzuki. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. Molecular Cell 81(7) 1397-1410 (2021)

M Higuchi, K Ishiyama, M Maruoka, R Kanamori, A Takaori-Kondo, N Watanabe. Paradoxical activation of c-Src as a drug-resistant mechanism. Cell reports 34(12) 108876-108876 (2021)

M Maruoka, S Kedashiro, Y Ueda, K Mizutani, Y Takai. Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. JOURNAL OF BIOLOGICAL CHEMISTRY 292(17) 6895-6909 (2017)

M Kitayama#, K Mizutani#, M Maruoka#(Co-first), K Mandai, S Sakakibara, Y Ueda, T Komori, Y Shimono, Y Takai. A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development JOURNAL OF BIOLOGICAL CHEMISTRY 291(11) 5817-5831 (2016)

M Maruoka, M Sato, Y Yuan, M Ichiba, R Fujii, T Ogawa, N Ishida-Kitagawa, T Takeya, N Watanabe. Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion BIOCHEMICAL JOURNAL 441 889-899 (2012)

M Sato#, M Maruoka#(Co-first), N Yokota, M Kuwano, A Matsui, M Inada, T Ogawa, N Ishida-Kitagawa, T Takeya. Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1 FEBS LETTERS 585(6) 834-840 (2011)

M Maruoka, J Suzuki, S Kawata, K Yoshida, N Hirao, S Sato, SP Goff, T Takeya, K Tani, T Shishido. Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases FEBS LETTERS 579(14) 2986-2990 (2005)