がん転移研究部・部長
主幹研究員

山口　英樹

研究テーマ
がん浸潤・転移の分子機構解明と新規がん治療法の開発

学位・資格

2002年

東京大学大学院医学系研究科博士課程修了　博士（医学）

所属学会

日本癌学会（評議員）

日本生化学会（評議員）

日本がん転移学会（評議員）

日本細胞生物学会

米国癌学会

主要論文

Miyazaki M, Nakabo A, Nagano Y, Nagamura Y, Yanagihara K, Ohki R, Nakamura Y, Fukami K, Kawamoto J, Umayahara K, Sakamoto M, Iwaya K, Yamaguchi H. Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis. Cancer Letters. 553: 215983 (2023)

Miyamoto S, Nagano Y, Miyazaki M, Nagamura Y, Sasaki K, Kawamura T, Yanagihara K, Imai T, Ohki R, Yashiro M, Tanaka M, Sakai R, and Yamaguchi H. Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma. Cancer Letters. 526: 335-345 (2022)

Nagamura Y, Miyazaki M, Nagano Y, Yuki M, Fukami K, Yanagihara K, Sasaki K, Sakai R, and Yamaguchi H. PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification. Oncogenesis. 10: 25 (2021)

Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, and Sakai R. Flotillin-1 regulates oncogenic signaling in neuroblastoma through receptor endocytosis of anaplastic lymphoma kinase. Cancer Research. 74: 3790-3801 (2014)

Kanemaru K, Nakamura Y, Sato K, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Asagiri M, Jamora C, Kouchi Z, Yamaguchi H, and Fukami K. Epidermal loss of phospholipase C δ1 results in myeloproliferation in mice. Nature Communications. 3: 963 (2012)

Yamaguchi H, Yoshida S, Muroi E, Yoshida N, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, and Fukami K: PI3-kinase signaling pathway mediated by p110α regulates invadopodia formation. Journal of Cell Biology. 193: 1275-1288 (2011)

Yamaguchi H, Takeo Y, Yoshida S, Kouchi Z, Nakamura Y, and Fukami K. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Research. 69: 8594-8602 (2009)

Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, and Condeelis J. Molecular mechanisms of invadopodium formation: The role of the N-WASP-Arp2/3 complex pathway and cofilin. Journal of Cell Biology. 168: 441-452 (2005)

Oikawa T, Yamaguchi H, Itoh T, Kato M, Ijuin T, Yamazaki D, Suetsugu S, and Takenawa T. PtIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nature Cell Biology. 6: 420-426 (2004)

Yamaguchi H, Miki H, and Takenawa T. Neural Wiskott-Aldrich syndrome protein is involved in hepatocyte growth factor-induced migration, invasion, and tubulogenesis of epithelial cells. Cancer Research. 62: 2503-2509 (2002)

Miki H, Yamaguchi H, Suetsugu S, and Takenawa T. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature. 408: 732-735 (2000)

Yamaguchi H, Miki H, Suetsugu S, Ma L, Kirschner MW, and Takenawa T. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. Proc. Natl. Acad. Sci. USA. 97: 12631-12636 (2000)