免疫システム研究部門
部長（主任研究員）

山口　智之

Research Map

研究テーマ：
免疫制御機構の解明と腫瘍免疫への応用
生命の原理の解明

学位・資格

1997年

東京大学　医学部医学科卒業　医籍登録

2003年

東京大学大学院　内科学専攻博士課程修了　医学博士

職歴

1997年

東京大学医学部付属病院内科

1998年

国立国際医療センター

2003－2011年

京都大学　再生医学研究所　（生体機能調節学分野、坂口志文研究室）

2003年

理化学研究所　研究員

2005年

京都大学再生医科学研究所　COE研究員

2007年

京都大学再生医科学研究所　特任助教

2008年

京都大学再生医科学研究所　助教

2011－2017年

大阪大学　免疫学フロンティア研究センター

2011年

大阪大学免疫学フロンティア研究センター　（実験免疫、坂口志文研究室）　特任准教授

2012年

大阪大学免疫学フロンティア研究センター　（１細胞１分子イメージング、柳田敏雄研究室）特任准教授

2013年

理化学研究所　生体システム研究センター　客員研究員（兼任）

2017年

野崎徳洲会病院付属研究所　医師兼研究員

所属学会

日本免疫学会

日本生物物理学会

主要論文

Tomoyuki Yamaguchi*
Learning processes in hierarchical pairs regulate entire gene expression in cells Scientific Reports 12(7549) 2022, doi:10.1038/s41598-022-10998-z
日本語解説記事

Tomoyuki Yamaguchi*, Toshie Shinagawa, Hisanobu Kobata, Hidemitsu Nakagawa Immunity against seasonal human coronavirus OC43 mitigates fatal deterioration of COVID-19 International Journal of Infectious Diseases 109 261-268 2021(Aug), doi:10.1016/j.ijid.2021.07.015
解説図

Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M Watanabe, Toshio Yanagida, Hideaki Fujita Activation probability of a single naïve T cell upon TCR ligation is controlled by T cells interacting with the same antigen-presenting cell. FEBS letters 595 1512-1524 2021(Apr) DOI:10.1002/1873-3468.14082

Yamaguchi Tomoyuki*, Teraguchi S., Furusawa C., Machiyama H., T. M Watanabe, Fujita H., Sakaguchi S., Yanagida T.: Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune-tolerance. International Immunology, 2019, 31(11): p743–753, https://doi.org/10.1093/intimm/dxz043 Selected as the Featured Article for the Month

Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata, UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses. Arterioscler Thromb Vasc Biol, 2017. 37(1): p. 66-74.

Matsumoto, T., N. Sasaki, T. Yamashita, T. Emoto, K. Kasahara, T. Mizoguchi, T. Hayashi, K. Yodoi, N. Kitano, T. Saito, T. Yamaguchi, and K. Hirata, Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol, 2016. 36(6): p. 1141-51.

Ichimura, T., L.D. Chiu, K. Fujita, H. Machiyama, T. Yamaguchi, T.M. Watanabe, and H. Fujita, Non-label immune cell state prediction using Raman spectroscopy. Sci Rep, 2016. 6: p. 37562.

Furusawa, C. and T. Yamaguchi, Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression. PLoS One, 2016. 11(9): p. e0163134.

Machiyama, H., T. Yamaguchi, Y. Sawada, T.M. Watanabe, and H. Fujita, SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane. FEBS J, 2015. 282(20): p. 4034-55.

Yamaguchi, T., A. Kishi, M. Osaki, H. Morikawa, P. Prieto-Martin, K. Wing, T. Saito, and S. Sakaguchi, Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression. Proc Natl Acad Sci U S A, 2013. 110(23): p. E2116-25.

Iyer, S.S., D.R. Latner, M.J. Zilliox, M. McCausland, R.S. Akondy, P. Penaloza-Macmaster, J.S. Hale, L. Ye, A.U. Mohammed, T. Yamaguchi, S. Sakaguchi, R.R. Amara, and R. Ahmed, Identification of novel markers for mouse CD4(+) T follicular helper cells. Eur J Immunol, 2013. 43(12): p. 3219-32.

Kinoshita, M., H. Kayama, T. Kusu, T. Yamaguchi, J. Kunisawa, H. Kiyono, S. Sakaguchi, and K. Takeda, Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol, 2012. 189(6): p. 2869-78.

Yamaguchi, T., J.B. Wing, and S. Sakaguchi, Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol, 2011. 23(6): p. 424-30.

Wing, K., T. Yamaguchi, and S. Sakaguchi, Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation. Trends Immunol, 2011. 32(9): p. 428-33.

Satou, Y., J. Yasunaga, T. Zhao, M. Yoshida, P. Miyazato, K. Takai, K. Shimizu, K. Ohshima, P.L. Green, N. Ohkura, T. Yamaguchi, M. Ono, S. Sakaguchi, and M. Matsuoka, HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog, 2011. 7(2): p. e1001274.

Teng, M.W., J.B. Swann, B. von Scheidt, J. Sharkey, N. Zerafa, N. McLaughlin, T. Yamaguchi, S. Sakaguchi, P.K. Darcy, and M.J. Smyth, Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion. Cancer Res, 2010. 70(7): p. 2665-74.

Sakaguchi, S., K. Wing, and T. Yamaguchi, Dynamics of peripheral tolerance and immune regulation mediated by Treg. Eur J Immunol, 2009. 39(9): p. 2331-6.

Sakaguchi, S., K. Wing, Y. Onishi, P. Prieto-Martin, and T. Yamaguchi, Regulatory T cells: how do they suppress immune responses? Int Immunol, 2009. 21(10): p. 1105-11.

Nagahama, K., Z. Fehervari, T. Oida, T. Yamaguchi, O. Ogawa, and S. Sakaguchi, Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. Int Immunol, 2009. 21(4): p. 379-91.

Miyara, M., Y. Yoshioka, A. Kitoh, T. Shima, K. Wing, A. Niwa, C. Parizot, C. Taflin, T. Heike, D. Valeyre, A. Mathian, T. Nakahata, T. Yamaguchi, T. Nomura, M. Ono, Z. Amoura, G. Gorochov, and S. Sakaguchi, Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity, 2009. 30(6): p. 899-911.

Kitoh, A., M. Ono, Y. Naoe, N. Ohkura, T. Yamaguchi, H. Yaguchi, I. Kitabayashi, T. Tsukada, T. Nomura, Y. Miyachi, I. Taniuchi, and S. Sakaguchi, Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity, 2009. 31(4): p. 609-20.

Wing, K., Y. Onishi, P. Prieto-Martin, T. Yamaguchi, M. Miyara, Z. Fehervari, T. Nomura, and S. Sakaguchi, CTLA-4 control over Foxp3+ regulatory T cell function. Science, 2008. 322(5899): p. 271-5.

Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono, Regulatory T cells and immune tolerance. Cell, 2008. 133(5): p. 775-87.

Onishi, Y., Z. Fehervari, T. Yamaguchi, and S. Sakaguchi, Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A, 2008. 105(29): p. 10113-8.

Yamaguchi, T., K. Hirota, K. Nagahama, K. Ohkawa, T. Takahashi, T. Nomura, and S. Sakaguchi, Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity, 2007. 27(1): p. 145-59.

Hirota, K., H. Yoshitomi, M. Hashimoto, S. Maeda, S. Teradaira, N. Sugimoto, T. Yamaguchi, T. Nomura, H. Ito, T. Nakamura, N. Sakaguchi, and S. Sakaguchi, Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med, 2007. 204(12): p. 2803-12.

Hirota, K., M. Hashimoto, H. Yoshitomi, S. Tanaka, T. Nomura, T. Yamaguchi, Y. Iwakura, N. Sakaguchi, and S. Sakaguchi, T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med, 2007. 204(1): p. 41-7.

Yamaguchi, T. and S. Sakaguchi, Regulatory T cells in immune surveillance and treatment of cancer. Semin Cancer Biol, 2006. 16(2): p. 115-23.

Yamaguchi, T. and S. Sakaguchi, Skin controls immune regulators. Nat Med, 2006. 12(12): p. 1358-9.

Fehervari, Z., T. Yamaguchi, and S. Sakaguchi, The dichotomous role of IL-2: tolerance versus immunity. Trends Immunol, 2006. 27(3): p. 109-11.

Ko, K., S. Yamazaki, K. Nakamura, T. Nishioka, K. Hirota, T. Yamaguchi, J. Shimizu, T. Nomura, T. Chiba, and S. Sakaguchi, Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med, 2005. 202(7): p. 885-91.

Kunisato, A., S. Chiba, T. Saito, K. Kumano, E. Nakagami-Yamaguchi, T. Yamaguchi, and H. Hirai, Stem cell leukemia protein directs hematopoietic stem cell fate. Blood, 2004. 103(9): p. 3336-41.

Saito, T., S. Chiba, M. Ichikawa, A. Kunisato, T. Asai, K. Shimizu, T. Yamaguchi, G. Yamamoto, S. Seo, K. Kumano, E. Nakagami-Yamaguchi, Y. Hamada, S. Aizawa, and H. Hirai, Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity, 2003. 18(5): p. 675-85.

Kunisato, A., S. Chiba, E. Nakagami-Yamaguchi, K. Kumano, T. Saito, S. Masuda, T. Yamaguchi, M. Osawa, R. Kageyama, H. Nakauchi, M. Nishikawa, and H. Hirai, HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood, 2003. 101(5): p. 1777-83.

Kumano, K., S. Chiba, A. Kunisato, M. Sata, T. Saito, E. Nakagami-Yamaguchi, T. Yamaguchi, S. Masuda, K. Shimizu, T. Takahashi, S. Ogawa, Y. Hamada, and H. Hirai, Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Immunity, 2003. 18(5): p. 699-711.